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Creatine and collagen are everywhere: in powders, gummies, social media ads, and coffee shop add-ins. But do these popular peptides actually do what people claim? In this episode, Ethan and Rachel take both molecules into the lab. Ethan walks through the fundamental biology—how creatine supports rapid energy production in muscle and how collagen peptides provide building blocks for connective tissue. Rachel brings the practical lens: Can creatine help with weight management or brain health? Does collagen really improve skin elasticity, or is that mostly marketing? They compare the strength of the evidence: creatine has decades of randomized trials in athletes and older adults, while collagen has promising but more preliminary findings, with many studies funded by ingredient makers. They also address who might benefit most, what doses are commonly studied, and why more is not better. The conversation avoids personalized advice but gives listeners a framework for evaluating these supplements for themselves. The episode closes with a clear summary of what we know, what we don’t, and the bottom line for anyone considering these popular powders.