Eric Pyrrhus

Mastodon @pyrrhus@mstdn.science

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Followers

449

Account age

3 yrs

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Known for

1/9
Some people feel that SARS-CoV-2 infection of the brain is "rare". (e.g. <10% of cases)
But can we really say that #SARSCoV2 infection of the nervous system is rare? 🤔
That's a question posed by neuroscientist Yan-Chao Li of Jilin University in his literature review and meta-analysis:
"What can CSF testing & brain autopsies tell us about viral neuroinvasion of SARS-CoV-2?"
https://doi.org/10.1

23 views 1/9 Some people feel that SARS-CoV-2 infection of the brain is "rare". (e.g. <10% of cases) But can we really say that #SARSCoV2 infection of the nervous system is rare? 🤔 That's a question posed by neuroscientist Yan-Chao Li of Jilin University in his literature review and meta-analysis: "What can CSF testing & brain autopsies tell us about viral neuroinvasion of SARS-CoV-2?" https://doi.org/10.1

9/9
One autopsy study, performed by a group of NIH investigators, correctly treated their samples with an RNA stabilizer as soon after death as possible.
This study found much higher levels of viral RNA than studies that neglected to use any RNA stabilizer:

8 views 9/9 One autopsy study, performed by a group of NIH investigators, correctly treated their samples with an RNA stabilizer as soon after death as possible. This study found much higher levels of viral RNA than studies that neglected to use any RNA stabilizer:

3 views 7/9 Therefore, the authors conclude that SARS-CoV-2 infection of the brain can not be assumed to be a rare occurrence:

2/9
Lead author Yan-Chao Li has spent the last 15 years studying coronavirus infections of the nervous system.
The authors point out that brain infections are extraordinarily difficult to detect at autopsy, partly due to the large, inhomogeneous nature of the brain tissue and the significant possibility of false negatives:

3 views 2/9 Lead author Yan-Chao Li has spent the last 15 years studying coronavirus infections of the nervous system. The authors point out that brain infections are extraordinarily difficult to detect at autopsy, partly due to the large, inhomogeneous nature of the brain tissue and the significant possibility of false negatives:

📊 Post engagement

Avg engagement / post

1.6%

Engagement vs followers

Nov 2022

On Mastodon since

🔥 Top post: 1/9 Some people feel that SARS-CoV-2 infection of the brain is " · 23 likes + reposts

📊 Activity & format

Posting cadence

9 / week

Toots daily — consistently active for a campaign window.

Content mix

Mostly images

Recent: 3 text · 9 image · 0 video.

Follower / following

1.5×

Follows 309 back. A more reciprocal / networked account.

Recent posts

View on Mastodon ↗

🔥 Top post 1/9 Some people feel that SARS-CoV-2 infection of the brain is "rare". (e.g. <10% of cases) But can we really say that #SARSCoV2 infection of the nervous system is rare? 🤔 That's a question posed by neuroscientist Yan-Chao Li of Jilin University in his literature review and meta… ★ 23

2/2 I really hate to do this, but the authors have a great explanation thread posted, um, over *there*: https://twitter.com/harschnitz/status/1696397763364229182 And also check out this previous paper from the authors: https://mstdn.scienc… ★ 5 1/2 Great work on #mpox #virus ( #MonkeyPox) from Lisa Bauer, Debby van Riel, & Oliver Harschnitz: "We found that MPXV infects and replicates more efficiently in astrocytes and microglia compared to cortical neurons, which unlike glial cel… ★ 16

9/9 One autopsy study, performed by a group of NIH investigators, correctly treated their samples with an RNA stabilizer as soon after death as possible. This study found much higher levels of viral RNA than studies that neglected to use a… ★ 8

8/9 In addition, one more significant methodological problem has been raised by other authors. Any viral RNA will rapidly degrade in any sample in a matter of hours, unless an RNA stabilizer is added to the sample right at time of sample c… ★ 2

7/9 Therefore, the authors conclude that SARS-CoV-2 infection of the brain can not be assumed to be a rare occurrence: ★ 3

6/9 Unfortunately, many autopsy studies appear to have simply chosen a few convenient parts of the brain to sample, increasing the likelihood of false negatives: ★ 1

5/9 And when there is observable inflammation, the authors note that observed brain infections might explain the observed brain inflammation better than any observed microvascular injury: ★ 1

4/9 The review notes that one reason why it is so hard to determine which part of the brain to test at autopsy is the fact that brain infections don't necessarily come with histologically observable inflammation: ★ 2

3/9 Furthermore, the meta-analysis suggests that CSF testing may not be much help in detecting brain infection, again due to a possibly large number of false negatives: ★ 2

2/9 Lead author Yan-Chao Li has spent the last 15 years studying coronavirus infections of the nervous system. The authors point out that brain infections are extraordinarily difficult to detect at autopsy, partly due to the large, inhomog… ★ 3 A fascinating perspective from Cornell's Maureen Hanson: "History offers persuasive evidence to suspect the enterovirus (EV) family of causing #MEcfs..." from: "The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome" https:… ★ 16

🐘 Community & instance

Home server

mstdn.science

Their home server on the fediverse — the instance a creator picks signals the community they belong to.

On Mastodon since

Nov 2022

Joined in the Twitter-exodus wave of late 2022 — part of the migration that made Mastodon a real destination.

💡 Facts

🗓️Joined Mastodon in 2022 — 3 years ago.

👁️Averages 7 views per post.

📤Posts about 9× per week.

🕵️ Fake follower check

Estimated

80/100

Excellent Credibility score

97%

Real Real audience

Low Fake-follower risk

High Data confidence

Est. 97% real, active audience · Low fake-follower risk.
Strong engagement (~1.6% of followers engage each post) — an active, real audience.
Established account (3+ years old).

Heuristic estimate from engagement, follower ratios, account age & growth — a screening signal, not a guarantee.

About

Scientist with an interest in flaviviruses, picornaviruses, and imaging technology. With undergraduate training at Columbia University and the University of Pennsylvania, and graduate training at U.C. Berkeley and UCSF Medical School, he has studied biomedical sciences, bioinformatics, biomedical imaging, biosensors, computer science, artificial intelligence, and business administration. Top image: Extracellular vesicles containing clusters of viruses. Image credit: Bird & Kirkegaard, 2015.

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Eric Pyrrhus

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