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🔥 Top post: Our study on fluoxetine's loss of efficacy to treat pediatric de · 1 likes + reposts
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Our study on fluoxetine's loss of efficacy to treat pediatric depression and the lack of acknowledgment of this finding in guidelines has been published.
https://www.jclinepi.com/article/S0895-4356(25)00349-X/fulltext
A longer thread can be found here:
https://bsky.app/profile…
Interested in learning how a small zombie-trial "infected" the body of evidence for fluoxetine to treat depression in children and adolecents?
Tomorrow, 2. February, 2:00–3:30pm (UK)
With @richlyus.bsky.social and me as presenters (via T…
Call for abstracts is open for the European Symposium on Suicide and Suicidal Behavior, ESSSB21 (Vilnius, 26-29 August 2026). Submit your symposium, workshop, oral, or poster by the deadlines. Details: https://www.esssb21.org/call-for-pap…
https://www.madinamerica.com/2025/10/a-call-for-evidence-based-fear-free-practice/
9. It was massive work. Big thanks to the team, and also Janssen who made their IPD available via YODA.
Thanks also to authors who supported us with additional data (I am convinced reaction by authors correlates with study quality).
8. Furthermore, the few trial where blinding was tested showed that blinding doesn't work well. In the few trials where ketemine was administered alongside an anesthetic procedure, the effect diminished. This suggests that the found short-…
7. Besides outcome switching, there are hints for problematic research practices in some trials. Some results just looked too good (no drop-out, effects sustained after weeks etc.). In one instance I contacted the journal bc there were sig…
6. In the risk of bias analyses, when checking the protocols or the entries on clinicaltrials.gov, we found many instances of outcome switching (check my timeline, I posted about this here for nearly all detected trials) and contacted the …
5. A striking finding: repeated doses were clearly not superior to single doses in the reduction of suicide ideation. This it at odds with the common practice of repeated doses. It was confirmed by another review which appeared after we co…
4. There was a larger reduction of suicide ideation in the first 3 days with ketamine/esketamine vs. placebo. This was found in previous reviews, too.
However, in subgroup analyses, we found that this applied to ketamine only. Esketamine'…
3. The results for suic behavior were inconclusive (the CI's overlapped with the null). Numerically, there were fewer suicide attempts with (es)ketamine arms vs. placebo, but there were numerically more suicides and deaths of any cause com…
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