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🔥 Top post: Many decision-makers in academia rely on publications as their m · 9 likes + reposts
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Many decision-makers in academia rely on publications as their main measure of academic success. Which behaviors of scientists are rewarded or devalued by this strategy? What could be alternative ways to measure academic success that promote better science?
Find out more in the …
These neurons don't require their postsynaptic partner to sort correctly. Only through the interactions of their growth cone filopodia in a confined, quasi-2D plane, each growth cone "guides" its neighbours to their final destination. A se…
An example occurs in the developing visual map of Drosophila. Here, ca. 5000 growth cones (from the roughly 800 single eyes of a fly's compound eye) re-sort from a retinotopic (one eye = one subregion in the brain) to a visuotopic arrangem…
Is such collective migration also found in developing brains? We think so, but with some twists. Not only can cells bodies migrate collectively (e.g. during sorting of neuronal precursors into layers and nuclei in the spinal cord), but als…
In zebrafish embryos during polster cell migration, AJs coordinate which side of a cell can form filopodia. This way, so called follower cells bias where the cells in front of them grow - basically steering from the backseat.
Local intera…
This enables a tissue-scale function: during wound closure, AJs move into opposite directions on the opposing fronts of epithelia (cells migrate forward by treadmilling F-actin). When the fronts meet, treadmilling strengthens AJ-binding (&…
Another cool feature: they can be moved around both from within (by treadmilling of the connected F-actin), and from without (if interacting AJs on other cells move).
The localization and function of AJs on individual cells can only be fu…
One cool molecular feature: they adapt their binding strength to mechanical stress they experience. This way, connected cells can buffer acute forces to not tear apart. But at the same time, the reduced adhesion of AJs in the absence of me…
Adherens Junctions (AJs) are cellular contact sites established by adhesive transmembrane proteins of the cadherin and nectin-family, and intracellular scaffold proteins. They link cells to each other not just by gluing their membranes, bu…
How do molecular features of protein complexes allow cells to behave collectively? And what can we learn from collective cell migration in epithelial and mesenchymal cells to understand brain development?
These questions motivated our rec…
More information to the project at: https://www.cos.io/rpcb
... and in our extended show notes to the episode at https://www.bihealth.org/en/quest/projects/spokes
If you haven't done so, check out the two summary papers about the results (…
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