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Our February cover shows a z-stack projection of spinning disk confocal images showing a C. elegans spermatheca filled with an oocyte. Actomyosin stress fibers (cyan) are labelled with GFP::ACT-1 and the RhoGEF RHGF-1 (magenta) is tagged with tagRFP.
From a study by Kela et al. (https://rupress.org/jcb/article/222/2/e202203105/213784/Tension-dependent-RHGF-1-recruitment-to-stress?utm_source=masto
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JCB is proud to serve as a home for exceptional advances in methods and resources that serve the full breadth of cell biology research. With our Tools format, authors convey their most innovative feats of imaging, tissue engineering, high-throughput screens, software, and more. Now for the first time, we have gathered a collection of exceptional Tools articles from recent issues. Read the collecti
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Our May cover shows scanning electron microscopy micrograph of the specific adhesion between an HIV-1–infected T lymphocyte (colored in green) and a macrophage (colored in gray) before fusion of the two cells, leading to a very efficient macrophage infection by HIV-1.
From Mascarau et al. (https://doi.org/10.1083/jcb.202205103)
Read JCB’s May Issue: https://rupress.org/jcb/issue/222/5
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Our August cover shows the structure of the human ER membrane protein complex (EMC) embedded in a lipid bilayer. From a study by Pleiner, Hazu, Tomaleri et al (https://doi.org/10.1083/jcb.202212007) characterizing a novel selectivity filter in the EMC that protects the integrity of the ER proteome by enforcing the fidelity of membrane protein sorting between organelles and substrate folding at the
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🔥 Top post: Our February cover shows a z-stack projection of spinning disk c · 6 likes + reposts
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Our February cover shows a z-stack projection of spinning disk confocal images showing a C. elegans spermatheca filled with an oocyte. Actomyosin stress fibers (cyan) are labelled with GFP::ACT-1 and the RhoGEF RHGF-1 (magenta) is tagged with tagRFP.
From a study by Kela et al.…
Our September Issue is out! Image shows spinning disk confocal micrographs of an early C. elegans embryo expressing mScarlet-I labeled Plekstrin homology domain to visualize cell membranes. The two endoderm precursor cells are pseudocolore…
Our August cover shows the structure of the human ER membrane protein complex (EMC) embedded in a lipid bilayer. From a study by Pleiner, Hazu, Tomaleri et al (https://doi.org/10.1083/jcb.202212007) characterizing a novel selectivity filte…
Our July cover shows a maximum projection of GCaMP6s Ca2+-sensor signal from a 30-min recording of the epidermal basal stem cell layer in a live mouse. The color scale indicates GCaMP6s signal across time, showing a diversity of spatiotemp…
Our June cover shows 4 cases of unilateral distribution of Cadm3 fused w/ GFP in WT donor retinal progenitor cells labeled w/ H2B-RFP in the p15+ zebrafish retina at 24 h post fertilization (hpf). Individual cases were imaged separately us…
Our May cover shows scanning electron microscopy micrograph of the specific adhesion between an HIV-1–infected T lymphocyte (colored in green) and a macrophage (colored in gray) before fusion of the two cells, leading to a very efficient m…
Our April cover shows wide-field image of a node of Ranvier in a myelinated axon stained for ADAM23 (green), βIV Spectrin (red; the node) and CASPR (gray; the paranode). ADAM23 is present in the juxtaparanodal axonal domain and engages wit…
Our March cover shows a maximum projection of Ashyba gossypii expressing the septin Cdc11a-GFP where color corresponds to the Z-height. Various septin structures can be observed in A. gosspyii: (1) interregion rings, which are bundled sept…
Chii Jou Chan: The positives of being under "pressure"
Chii Jou (Joe) Chan (National University of Singapore) investigates how tissue mechanics and fluid pressure regulate mammalian development, with a special focus on folliculogenesis an…
Spotlight: Enrica Bianchi and Gavin J. Wright discuss work by Brukman and colleagues (https://rupress.org/jcb/article/222/2/e202207147/213693/A-novel-function-for-the-sperm-adhesion-protein?utm_source=mastodon) that provides evidence that …
JCB is proud to serve as a home for exceptional advances in methods and resources that serve the full breadth of cell biology research. With our Tools format, authors convey their most innovative feats of imaging, tissue engineering, high-…
New Spotlight: Annemiek Veldsink and Liesbeth Veenhoff (University of Groningen) discuss work from the Ünal lab (UC Berkeley), which reveals two distinct processes that remodel the nuclear pore complex basket during budding yeast meiosis. …
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