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In a paper now out in Angewandte, we have applied directed evolution on the nonribosomal peptide synthetase (#NRPS) making the peptide #antibiotic gramicidin S. Just a few mutations were sufficient to make the NRPS incorporate the non-standard building block piperazic acid instead of proline into the peptide. Directed evolution of NRPSs is needed to adapt the structures of antibiotic peptides to h
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🏆 Thrilled to share fantastic news! 🎉 Honored with the "Goldene Kreide" Teaching Award in Chemistry by amazing students at the Faculty of Biology, Chemistry & Earth Sciences, Universität Bayreuth! 🧪📚
Thanks for the votes, Lena Glöckler, Fachschaft, for impeccable organization and Prof Frank Hahn for inviting me to this position. Teaching in Bayreuth was a joy! Special thanks to the OCI team Dr Tho
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Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of t
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🔥 Top post: In a paper now out in Angewandte, we have applied directed evolu · 7 likes + reposts
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In a paper now out in Angewandte, we have applied directed evolution on the nonribosomal peptide synthetase (#NRPS) making the peptide #antibiotic gramicidin S. Just a few mutations were sufficient to make the NRPS incorporate the non-standard building block piperazic acid inste…
Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity prof…
Welcome on Mastodon and Servus, dear @LacknerLab. 👋 I look forward to interesting posts about the #biochemistry of #naturalproducts and #synbio ! ⚗️ 🦠
I am thrilled to announce that our lab has joined @Uni_Stuttgart and I have accepted the position as Professor of Technical Biochemistry! 🔬🥂 I am honored to follow in the footsteps of Prof. Bernhard Hauer, whose contributions to the field …
🏆 Thrilled to share fantastic news! 🎉 Honored with the "Goldene Kreide" Teaching Award in Chemistry by amazing students at the Faculty of Biology, Chemistry & Earth Sciences, Universität Bayreuth! 🧪📚
Thanks for the votes, Lena Glöckler, Fa…
Good news at the start of 2024! Is Zosurabalpin the solution against dangerous infections with resistant A. baumannii? This clinical candidate discovered at #Roche in Basel inhibits the lipopolysaccharide transport. The promising new #anti…
@dfg_public Does anyone know if the RSS Feed from #DFG has been deactivated on purpose? This website is no longer available:
https://www.dfg.de/en/service/rss
#ChuckNorris has an H-index of 50 only for his uncitable items.
Generative AI may be hallucinating interesting research ideas: https://www.nature.com/articles/d41586-023-03596-0
I am also hoping for an AI that checks scientific ideas for novelty and validity against the literature.
Hi @Florian_FBredy ! Good to see you in the #Chemiverse #chemicalbiology
Correspondence in Nature: "Mastodon: a move to publicly owned scholarly knowledge"
https://www.nature.com/articles/d41586-023-00486-3
I am excited that @LeibnizHKI has joined Mastodon! I am looking forward to great #scicomm about #InfectionBiology, #NaturalProducts and more. Welcome!
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