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David Schnettler

David Schnettler

Mastodon @davidschnettler@mstdn.science
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🔒 Paid proposals held safely in escrow — released only when the work's approved.

📣Sponsored postOne disclosed post (toot) with your link and message. $12→ 🧵Sponsored threadA multi-post explainer or story — the fediverse rewards dept… $30→ 📦Product seeding / honest reviewSend me your product — I post a disclosed, honest take. Auth… $16→ 📌Pinned sponsored postA disclosed post pinned to the top of my profile for the mon… $36/mo→ 🔗Profile link (bio field)Your link in one of my profile metadata fields for the month… $18/mo→ 🔁Boost packageI boost (repost) your account's toots through the month — di… $24/mo→ 🏛️Instance / community sponsorshipSponsor the server I run — a sponsor line in the About/rules… $30/mo→ 🤝Mutual boost collabWe boost each other across instances — a value swap between … Swap→ 🎬UGC HireBranded content for your own channels & ads from $50→ 🎙️Podcast guest spotInvite David Schnettler onto your podcast (~45 min, remote) $25→ 📞1:1 ConsultPaid video call — advice, coaching or Q&A $75/hr→

Every booking is a normal escrow-protected deal.

Followers
57
Account age
3 yrs
🎁 Free analysisfor David Schnettler
🕵️Fake Followers CheckReal-audience % & bot risk→ 📊Engagement rateBenchmarked vs. peers→ 💰What they chargeFair sponsored-post price→

Known for

Happy to see our preprint out on #bioRxiv! We screened #denovodesigned proteins for #phosphoesterase activity in #microfluidic droplets – and found truncated peptides that dynamically oligomerise to proficiently break down cAMP! This project from my time at the Hollfelder lab at the University of #Cambridge was a collaboration with the Hecht lab at #Princeton University. Special thanks to Michael5 views Happy to see our preprint out on #bioRxiv! We screened #denovodesigned proteins for #phosphoesterase activity in #microfluidic droplets – and found truncated peptides that dynamically oligomerise to proficiently break down cAMP! This project from my time at the Hollfelder lab at the University of #Cambridge was a collaboration with the Hecht lab at #Princeton University. Special thanks to Michael

📊 Post engagement

2
Avg engagement / post
3.5%
Engagement vs followers
Nov 2022
On Mastodon since

🔥 Top post: Happy to see our preprint out on #bioRxiv! We screened #denovod · 5 likes + reposts

📊 Activity & format

Posting cadence
0.17 / week
A lower-frequency account — each post lands with more weight.
Content mix
Mostly text
Recent: 11 text · 1 image · 0 video.
Follower / following
1.1×
Follows 53 back. A more reciprocal / networked account.

Recent posts

View on Mastodon ↗
🔥 Top post Happy to see our preprint out on #bioRxiv! We screened #denovodesigned proteins for #phosphoesterase activity in #microfluidic droplets – and found truncated peptides that dynamically oligomerise to proficiently break down cAMP! This project from my time at the Hollfelder lab a… ★ 5
In this project, we screened de novo designed protein libraries without natural ancestry for function, using #microfluidic droplets - and massively enriched short, truncated protein fragments. Turns out that these ≈ 40- to 60-residue fragm… This project was a wonderful collaboration between the Hollfelder Lab at @cambridge_uni and the Hecht Lab at Princeton, with brilliant contributions from Adrian Bunzel from ETH Zurich. Huge thanks to all co-authors, with a special shoutout… If you've ever done a bit of #ProteinEngineering or #DirectedEvolution you know that funny things can happen 🤯 – and sometimes it's worth following up! I'm excited to share that our paper is finally out in Nature Chemistry! 🎉 Read it he… ★ 2 🎉 Excited to share that I've been awarded the NOMIS-ETH Postdoctoral Fellowship to do research on the origin of life! Starting this September, I'll join the Panke group at the Department of Biosystems Science and Engineering (D-BSSE) in Ba… ★ 1 Conclusions: - Microfluidic droplet sorting is an extremely powerful tool for #proteinengineering - Cys-triad enzymes might be predisposed and well suited for evolution towards pesticide decontamination or catalytic bioscavengers (6/6) By using steady and transient state #kinetics as well as linear free-energy relationships (#LFER) we show that the breakup of the covalent phosphoryl intermediate – which is the 'lethal' step for acetylcholinesterase – is surprisingly fast… By combining smart libraries with the ultrahigh throughput of droplet #microfluidics, we increased its catalytic efficiency by 360-fold in only two rounds of evolution, matching the activity of most metal-dependent phosphotriesterases. Bu… Here, we show that an alternative motif for phosphotriester hydrolysis exists, starting #DirectedEvolution from a metal-independent alpha/beta hydrolase which Pierre-Yves identified using functional #metagenomics: https://www.nature.com/a… ★ 2 Phosphotriesterases have evolved rapidly in the last decades in response to the large-scale pollution of environments with xenobiotic organophosphates (used for example as pesticides) – they could well be the youngest enzymes on the planet… Excited to share my very first paper which was just published in #JACS: https://pubs.acs.org/doi/10.1021/jacs.2c10673 In this work carried out during my PhD together with Jamie Klein, Tomasz Kaminski, and Pierre-Yves Colin in the Hollfeld… ★ 3 Is (pre-publication) peer review actually any good? A very thought-provoking article by Adam Mastroianni: https://experimentalhistory.substack.com/p/the-rise-and-fall-of-peer-review #PeerReview #academia #AcademicPublishing #AcademicMastod… ★ 1

🐘 Community & instance

Home server
mstdn.science
Their home server on the fediverse — the instance a creator picks signals the community they belong to.
On Mastodon since
Nov 2022
Joined in the Twitter-exodus wave of late 2022 — part of the migration that made Mastodon a real destination.

💡 Facts

🗓️Joined Mastodon in 2022 — 3 years ago.
👁️Averages 2 views per post.
📤Posts about 0.2× per week.

🕵️ Fake follower check

Estimated
80/100
Excellent Credibility score
97%
Real Real audience
Low Fake-follower risk
High Data confidence
  • Est. 97% real, active audience · Low fake-follower risk.
  • Strong engagement (~3.5% of followers engage each post) — an active, real audience.
  • Established account (3+ years old).

Heuristic estimate from engagement, follower ratios, account age & growth — a screening signal, not a guarantee.

About

Postdoctoral researcher at ETH Zurich. Previously PhD student in the Hollfelder Lab at University of Cambridge. Interested in all aspects of #proteinengineering and #proteinevolution.

🔀 Audience overlap

Estimated

Estimated shared audience with similar creators — useful for avoiding overlap (or doubling down) when planning a campaign.

Faux Faux 18% Se toinen Petteri Se toinen Petteri 14% Tom Schmidt #DEI 🥄🇺🇸:v26: Tom Schmidt #DEI 🥄🇺🇸:v26: 14% Sir Robin Sir Robin 13% Markus :bayern: 🇩🇪 🇪🇺 Markus :bayern: 🇩🇪 🇪🇺 12% Haudrauf Haudrauf 11%

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